Valproic Acid
Information
- Drug Name
- Valproic Acid
- Description
- Entry(CIViC)
- 2
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| uveal melanoma | BAP1 MUTATION BAP1 MUTATION | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 22038994 | Detail |
| acute myeloid leukemia | NPM1 EXON 12 MUTATION NPM1 EXON 12 MUTATION | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 2 | 24797300 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Somatic and germline BAP1 mutations are associated... | BAP1 | BAP1 MUTATION BAP1 MUTATION | Sensitivity | true | CIViC Evidence | detail |
| For patients with NPM1 mutation that achieved CR f... | NPM1 | NPM1 EXON 12 MUTATION NPM1 EXON 12 MUTATION | Sensitivity | true | CIViC Evidence | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02624128 | Active, not recruiting | Phase 2 | Valproic Acid Plus Cisplatin and Cetuximab in Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck | February 23, 2015 | December 2023 |
| NCT01552434 | Active, not recruiting | Phase 1 | Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease | March 16, 2012 | March 31, 2026 |
| NCT01817751 | Active, not recruiting | Phase 2 | Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma | April 11, 2013 | October 30, 2027 |
| NCT03357757 | Active, not recruiting | Phase 2 | Avelumab With Valproic Acid in Virus-associated Cancer | February 7, 2018 | February 26, 2027 |
| NCT02068586 | Active, not recruiting | Phase 2 | Sunitinib Malate or Valproic Acid in Preventing Metastasis in Patients With High-Risk Uveal Melanoma | November 19, 2014 | December 31, 2025 |
| NCT00084981 | Completed | Phase 1 | Decitabine and Valproic Acid in Treating Patients With Non-Small Cell Lung Cancer | April 2004 | |
| NCT00088452 | Completed | Phase 3 | Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study | July 2004 | August 31, 2016 |
| NCT00107458 | Completed | Phase 1 | Valproic Acid in Treating Young Patients With Recurrent or Refractory Solid Tumors or CNS Tumors | May 2005 | March 2012 |
| NCT00109824 | Completed | Phase 1 | Decitabine With or Without Valproic Acid in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma | March 2006 | |
| NCT00175812 | Completed | Phase 1/Phase 2 | Differentiation Induction in Acute Myelogenous Leukemia | November 2004 | November 2009 |
| NCT00246103 | Completed | Phase 1 | Phase I Trial of Valproic Acid and Epirubicin in Solid Tumor Malignancies | March 2004 | April 2008 |
| NCT00264680 | Completed | Spanish Validation Of Quality of Life Questionnaire (QOLIE-10) For Epilepsy | October 1, 2003 | March 1, 2006 | |
| NCT00289952 | Completed | Phase 2 | Valproic Acid and Its Effects on HIV Latent Reservoirs | June 2006 | December 2012 |
| NCT00302159 | Completed | Phase 2 | Valproic Acid With Temozolomide and Radiation Therapy to Treat Brain Tumors | March 2006 | November 2014 |
| NCT00326170 | Completed | Phase 2 | Phase II 5-Azacytidine Plus VPA Plus ATRA | July 2005 | December 2007 |
| NCT00374075 | Completed | Phase 1 | Study of Safety and Dosing Effect on SMN Levels of Valproic Acid (VPA) in Patients With Spinal Muscular Atrophy | September 2003 | February 2006 |
| NCT00385710 | Completed | Phase 2 | Trial of Valproic Acid in Patients With Progressive Supranuclear Palsy (Depakine) | November 2006 | July 2010 |
| NCT00414310 | Completed | Phase 2 | Decitabine (DAC) w/ or w/o Valproic Acid (VPA) in Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML) | December 2006 | May 2015 |
| NCT00439673 | Completed | Phase 2 | PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS | May 2007 | July 2010 |
| NCT00495872 | Completed | Phase 1 | Valproic Acid-Based 2-Agent Oral Regimens for Patients With Advanced Solid Tumor | June 2007 | |
| NCT00496444 | Completed | Phase 1 | Azacytidine and Valproic Acid in Patients With Advanced Cancers | May 2005 | October 2009 |
| NCT02608736 | Completed | Early Phase 1 | Chemoprevention of Head and Neck Squamous Cell Carcinoma (HNSCC) With Valproic Acid | December 2015 | July 2017 |
| NCT00004758 | Completed | Phase 2 | Phase II Randomized Study of Early Surgery Vs Multiple Sequential Antiepileptic Drug Therapy for Infantile Spasms Refractory to Standard Treatment | November 1993 | |
| NCT00075010 | Completed | Phase 1/Phase 2 | Phase I/II Study of Decitabine and Valproic Acid in Relapsed/Refractory Leukemia or Myelodysplastic Syndromes | January 23, 2004 | November 8, 2006 |
| NCT00075777 | Completed | N/A | Valproic Acid in Treating Patients With Kaposi's Sarcoma | February 2005 | February 2008 |
| NCT00079378 | Completed | Phase 1 | Decitabine and Valproic Acid in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia or Previously Treated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma | February 2004 | |
| NCT00529022 | Completed | Phase 1 | Azacitidine and Valproic Acid Plus Carboplatin in Patients With Ovarian Cancer | August 2007 | October 2012 |
| NCT00530907 | Completed | Phase 1 | Valproic Acid and Bevacizumab in Patients With Advanced Cancer | June 2007 | November 2013 |
| NCT00563992 | Completed | Phase 1 | Effectiveness of Lithium and Valproate in Treating High-Risk Bipolar Disorder | January 2001 | October 2008 |
| NCT00605657 | Completed | Phase 1/Phase 2 | Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS) | January 2008 | September 2011 |
| NCT00609245 | Completed | Phase 4 | Effect of Valproic Acid Concentration on Photic Response | December 2007 | December 2008 |
| NCT00681980 | Completed | Phase 3 | Use Of Valproid Acid To Treat Tropical Spastic Paraparesis/HTLV-1-Associated Myelopathy (TSP/HAM) | February 2008 | December 2015 |
| NCT00787930 | Completed | Bipolar Disorder in Late Life | October 2005 | December 2011 | |
| NCT00879437 | Completed | Phase 2 | Valproic Acid, Radiation, and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma | September 1, 2009 | October 2, 2017 |
| NCT01030094 | Completed | A Cross-sectional Study to Investigate the Effect of Topiramate on Bone and Mineral Metabolism in Female Participants With Epilepsy | February 2007 | April 2009 | |
| NCT01115959 | Completed | Phase 4 | Seizures Post Intracerebral Hemorrhage | February 2003 | December 2008 |
| NCT01182285 | Completed | Phase 2 | A Phase II Trial of Valproic Acid in Patients With Advanced Thyroid Cancers of Follicular Cell Origin | September 24, 2010 | April 28, 2016 |
| NCT01233609 | Completed | Phase 2 | Trial of Oral Valproic Acid for Retinitis Pigmentosa | November 2010 | December 2015 |
| NCT01399515 | Completed | Phase 2 | Efficacy and Safety of Oral Valproic Acid for Retinitis Pigmentosa | March 2011 | November 2015 |
| NCT01548066 | Completed | Phase 2 | The Efficacy and Safety of Topical Valproic Acid in Preventing Hair Loss | September 2011 | June 2012 |
| NCT01695122 | Completed | Phase 2 | Valproic Acid and Platinum-based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma | September 2012 | November 2014 |
| NCT01729598 | Completed | Early Phase 1 | Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study | April 2012 | October 2014 |
| NCT01738815 | Completed | Early Phase 1 | Impact of Valproate on Angiogenesis and Histone Deacetylation in Bladder Cancer | December 2011 | April 2014 |
| NCT01928849 | Completed | Phase 2 | Valproic Acid for the Prevention of Post-Amputation Pain | December 2013 | September 26, 2017 |
| NCT01951560 | Completed | Phase 1 | A Study to Evaluate the Safety and Tolerability of Valproic Acid in Healthy Volunteers (Part 1) | September 2013 | May 2016 |
| NCT01960075 | Completed | Phase 3 | Established Status Epilepticus Treatment Trial | October 2015 | May 2019 |
| NCT02456454 | Completed | Phase 3 | Controlled Trial of Valproate Versus Risperidone in Young Children With Bipolar Disorder | January 2006 | June 2010 |
| NCT02520115 | Completed | Phase 1 | Folate Receptor in Diagnosing Ovarian Cancer Using Serum Samples From Patients With Newly Diagnosed Pelvic Mass or Previously Diagnosed Ovarian Cancer | August 2015 | November 2018 |
| NCT00000629 | Completed | Phase 1 | The Effects of Valproic Acid on Zidovudine Glucuronidation and Pharmacokinetics in HIV-Infected Patients. | ||
| NCT02789813 | Completed | Phase 2 | Influence of Valproic Acid on Extinction-based Therapy in Patients With Fear of Spiders. | July 2016 | June 30, 2018 |
| NCT02870283 | Completed | Phase 4 | Cost- Effectiveness and Quality of Life Assessment in Mood Disorder | May 2010 | September 2015 |
| NCT03385525 | Completed | Phase 1 | Study to Evaluate the Effect of UGT Inhibition by Valproic Acid on the Pharmacokinetics of BIIB074 | September 12, 2017 | October 13, 2017 |
| NCT03525730 | Completed | Phase 1/Phase 2 | LRAs United as a Novel Anti-HIV Strategy. | April 18, 2018 | October 1, 2020 |
| NCT03632915 | Completed | Pharmacokinetics of Antiepileptics in Patients on CRRT | November 20, 2017 | December 31, 2019 | |
| NCT03885947 | Completed | Phase 1 | VPA Expanded UCB Transplantation for Treatment of Patients With Hematological Malignancies | February 21, 2019 | March 10, 2021 |
| NCT04482764 | Completed | Phase 1 | Valproic Acid in Treating Cyanotic Breath Holding Spells | January 30, 2017 | December 30, 2018 |
| NCT06199557 | Not yet recruiting | Phase 1/Phase 2 | A Study to Investigate Treatment of HU and VPA, or 6-MP and VPA in Unfit AML/HR-MDS Patients | January 25, 2024 | September 30, 2029 |
| NCT01898104 | Recruiting | Phase 1/Phase 2 | Preoperative Valproic Acid and Radiation Therapy for Rectal Cancer | May 2012 | April 2024 |
| NCT03196466 | Recruiting | Population Pharmacokinetics of Antiepileptic in Pediatrics | June 19, 2017 | June 19, 2026 | |
| NCT05697614 | Recruiting | Phase 4 | The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children | March 1, 2023 | June 30, 2023 |
| NCT02446431 | Recruiting | Early Phase 1 | Metronomic Therapy for Pediatric Patients With Solid Tumors at High Risk of Recurrence | July 2014 | July 2029 |
| NCT05821556 | Recruiting | Phase 2 | Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma Patients | June 12, 2023 | June 2026 |
| NCT04310176 | Recruiting | Phase 2 | Valproic Acid in Combination With Bevacizumab and Oxaliplatin/Fluoropyrimidine Regimens in Patients With Ras-mutated Metastatic Colorectal Cancer | May 24, 2019 | November 2024 |
| NCT06248931 | Recruiting | Phase 3 | Valproate Versus Topiramate in Migraine | February 1, 2024 | February 20, 2025 |
| NCT03048084 | Recruiting | Phase 4 | Seizure Treatment in Glioma | February 1, 2018 | January 1, 2028 |
| NCT02343575 | Terminated | Phase 4 | Valproic Acid for Treatment of Hyperactive or Mixed Delirium in ICU | January 2015 | January 2018 |
| NCT02374567 | Terminated | Phase 3 | Pharmacovigilance in Gerontopsychiatric Patients | January 2015 | June 28, 2017 |
| NCT00437957 | Terminated | Phase 1 | Phase I Study of Temozolomide, Valproic Acid and Radiation Therapy in Patients With Brain Metastases | December 2006 | April 2009 |
| NCT00670046 | Terminated | Phase 2 | Valproic Acid in Treating Patients With Progressive, Non-Metastatic Prostate Cancer | May 2008 | July 2012 |
| NCT01674010 | Terminated | Phase 2 | Safety and Efficacy Study of ELND005 as an Adjunctive Maintenance Treatment in Bipolar I Disorder | August 2012 | June 2014 |
| NCT01007695 | Terminated | Phase 1 | Molecular Signature of Valproic Acid in Breast Cancer With Functional Imaging Assessment - a Pilot | May 2010 | May 2015 |
| NCT01010958 | Terminated | Phase 1 | Adjuvant Valproate for High Grade Sarcomas | October 2009 | February 2014 |
| NCT00298857 | Terminated | Phase 4 | A Pharmacokinetic Study to Compare the Dosing of Valproic Acid in Subjects With Different Body Weights | March 2006 | March 2007 |
| NCT00358319 | Terminated | Phase 1/Phase 2 | Phase I/II Trial of Valproic Acid and Karenitecin for Melanoma | March 2005 | April 2007 |
| NCT01204450 | Terminated | Phase 1 | Temsirolimus and Valproic Acid in Treating Young Patients With Relapsed Neuroblastoma, Bone Sarcoma, or Soft Tissue Sarcoma | November 2009 | March 2013 |
| NCT02872428 | Terminated | Phase 1 | A Study to Evaluate the Safety and Tolerability of Valproic Acid in Trauma Patients(Part 2) | November 2016 | September 29, 2017 |
| NCT00519181 | Terminated | N/A | Safety and Efficiency Study of Valproic Acid In HAM/TSP | March 2006 | June 2007 |
| NCT00525135 | Terminated | Phase 2 | Valproic Acid (Depakote ER) in Patients With Advanced Thyroid Cancer | August 2007 | March 2009 |
| NCT02893371 | Terminated | Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies | September 2016 | June 30, 2019 | |
| NCT00312546 | Terminated | Phase 1 | Study of Valproic Acid to Treat HIV Infected Adults | June 2006 | October 2009 |
| NCT00854581 | Terminated | Phase 4 | Zidovudine, Interferon Alfa-2b, PEG-Interferon Alfa-2b in Patients With HTLV-I Associated Adult T-Cell Leukemia/Lymphoma | November 2007 | November 2011 |
| NCT01333631 | Unknown status | Phase 2 | Valproic Acid With Chemoradiotherapy for Pancreatic Cancer | June 2011 | July 2015 |
| NCT02761291 | Unknown status | Phase 1 | Study of Cytolytic Viral Activation Therapy (CVAT) for Recurrent/Metastatic Nasopharyngeal Carcinoma | May 2016 | |
| NCT01203735 | Unknown status | Phase 1/Phase 2 | Valproic Acid With Chemoradiotherapy for Non-Small-Cell Lung Cancer | February 2011 | February 2015 |
| NCT02896270 | Unknown status | Phase 2/Phase 3 | Valproic Acid for Idiopathic Nephrotic Syndrome | October 2016 | December 2019 |
| NCT00810680 | Unknown status | N/A | Study of Efficacy and Safety of Valproic Acid in Chronic Lymphocytic Leukemia (CLL) | September 2008 | March 2009 |
| NCT04486092 | Unknown status | N/A | Mood Stabilizer-induced Metabolic Abnormalities in Bipolar Disorder | February 2015 | July 2021 |
| NCT01016990 | Unknown status | Phase 2 | Valproic Acid in Treating Patients With Previously Treated Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Chronic Lymphocytic Leukemia | August 2009 | |
| NCT04531592 | Withdrawn | Phase 2 | Valproic Acid (VPA) for Acute Kidney Injury (AKI) in Liver Transplant Patients | January 2022 | June 2023 |
| NCT00181220 | Withdrawn | Phase 1 | Valproic Acid in the Induction of EBV Lytic Cycle Antigen Expression in Nasopharyngeal Carcinoma | April 2004 | September 2006 |
| NCT01861990 | Withdrawn | Phase 1 | Valproic Acid in Childhood Progressive Brain Tumors | May 2013 | December 2013 |